Anti-tumor antibody profile analysis to harness the potentials of B cells in melanomas and the natural humoral immune response
نویسندگان
چکیده
Objectives Natural humoral immune response and autoimmune mechanisms have great importance in keeping the balance of tumorimmunity, although it has not yet been fully understood. We aimed to reveal potential antitumor immune response by immunoglobulin (Ig) profile analysis of patients with metastatic melanomas. Methods A complex panel assay has been performed at expressed DNA and protein levels on antibodies originating from patients’ peripheral blood (n = 92) or cancerous tissue biopsies (n= 87) (ETT TUKEB 1646202/2010). Heavy and light chain immunoglobulin variable gene regions were sequenced and analysed with Vector NTI Advance
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2013